Medium impact
Myalept® (metreleptin) (Revised)
Humana·Effective Jan 1, 2017
Humana updated its Myalept (metreleptin) prior authorization policy for Medicare Advantage members, effective January 1, 2017, with a recent revision dated July 22, 2026. The policy requires prior authorization for Myalept subcutaneous solution when treating congenital or acquired generalized lipodystrophy, with strict exclusions for partial lipodystrophy, liver disease (including NASH), HIV-related lipodystrophy, and generalized obesity. The policy emphasizes REMS program requirements, boxed warnings regarding anti-metreleptin antibodies and lymphoma risk, and approval duration determined by plan year or clinical review.