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Orthopedic Applications of Platelet-Rich Plasma
Blue Cross & Blue Shield of Mississippi·Orthopedics, Sports Medicine, Pain Management +1 more·Medical Policy
We identified it
Jun 20, 2026
Summary
Blue Cross Blue Shield has updated their policy on platelet-rich plasma (PRP) treatments, maintaining that all orthopedic applications of PRP remain investigational and are not covered. This includes both primary injections for conditions like tendinopathy and osteoarthritis, as well as adjunctive use in surgical procedures.
Action Required
Immediately: Billing team must verify that CPT code 0232T (platelet-rich plasma injection) is flagged as non-covered/investigational in billing system for all Blue Cross Blue Shield plans. Notify providers that all PRP procedures for orthopedic conditions will be denied by BCBS. Update encounter forms and EMR templates to alert providers of non-coverage status. Claims submitted for these services will be denied.